As detailed below, gadd45 genes have been implicated in the control of cell cycle arrest[25,26,28,38,58], DNA repair[39-41], cell survival[41,63,76-79], apoptosis[33,68,75,69,42,43,80-82], senescence[67], and susceptibility of cells for transformation in vitro and in tumor development in vivo[67,83]. This evidence concerns the gene GADD45A and neoplasm.