We could inhibit RA serum IgM antibodies to bind to CSA, CSB, CSC, KS, HS and HA by Duolite (58.98% ± 0.88%, 59.56% ± 1.53%, 60.77% ± 2.17%, 59.93% ± 0.14%, 64.80% ± 1.76%, 45.95% ± 181.42%, respectively). This evidence concerns the gene CD40LG and rheumatoid arthritis.