We could also identify similar IgM cross-reactions between GAGs and Zymosan in the case of RA serum antibodies (CSA was 2.9%, 10.7% and36.4%; CSB was 11.8%, 19.7% and 40.5%; CSC 12.6%, 17.5% was 48.3%; KS was 11.8%, 23.5% and 50.6%; HS was 4.5%, 11.7% and 22.1%; HA was 15.0%, 207% and 33.0% inhibitions were detected using 0.5 μg/μl, 5 μg/μl and 50 μg/μl inhibitor molecules, respectively). Here, CD40LG is linked to rheumatoid arthritis.