In order to assess the contribution of the genetic variability to plasma triglyceride levels, haplotype analyses were performed in subjects without metabolic syndrome using the 5 SNPs in the following order: APOA5 (Ser(C)19Trp(G), -12,238T>C),APOA4 (Thr(A)347Ser(T)) and APOC3 (-482C>T, 3238C>G). This evidence concerns the gene APOA4 and metabolic syndrome.