Fanconi anemia (FA) is an autosomal recessive bone marrow failure syndrome due to mutations in at least 13 different genes (FANCA, B, C, D1/BRCA2, D2, E, F, G, I, J/BRIP1, L, M and N/PALB2) [4,5] and the incidences of acute myeloid leukaemia and certain solid tumours are all greatly increased in homozygotes [6]. This evidence concerns the gene PALB2 and Friedreich ataxia.