In support of theprosurvival activity of PPARγ in T-cell malignancies, Ferreira-Silva et al. veryrecently showed that RNAi-mediated silencing of PPARγ in Jurkat T-cells caused increased DNAfragmentation and apoptosis as well as G2/M cell cycle arrest, arguing that thereceptor, proper, promotes the viability of the tumor cells [43]. Here, PPARG is linked to neoplasm.