In light of boththese findings and the overexpression of PPARγ in many cancers, it is reasonable tohypothesize that the function of PPARγ in cancer is to confer a survival advantageupon the malignant cells, allowing them to survive in an adverse environment.As a result of fast growth, the center of a three dimensional tumor mass isoften deprived of oxygen, growth factors, glucose, and other nutrients due toexcessive demand and insufficient vascularization. The gene discussed is PPARG; the disease is cancer.