PPARG and neoplasm: However, in a murine follicularthyroid cancer model containing a dominant-negative mutant form of thyroidhormone receptor β (TRβPV/PV), loss of one PPARγ allele led to increased weight oftumor-bearing thyroid gland, increased lung metastasis, and shortened survival.In addition, rosiglitazone treatment of TRβPV/PV mice reducedthyroid weight, and tumor progression [65], suggesting atumor-suppressing role for PPARγ.