PPARG and thyroid gland follicular carcinoma: (3) Using cell lines transfected with PPARγ or thefusion protein, it is shown that expression of some genes, including angiogenicfactors PGF and ANGPTL4, is specifically upregulated by the fusion protein, particularlyin the absence of ligand, indicating that the fusion protein is constitutively active.Taken together, these experimental data suggest that the translocation enhancesthe function of PPARγ in a waythat contributes to the development or progression of follicular carcinoma of thethyroid [29].