CCND1 and neoplasm: Cyclin D1 levels, on the other hand, were elevated mainly in luminal tumours including noticeably higher expression in many luminal B tumours (Figures 1 and 2d); in addition, it was recently reported that there are often high level gains of the 11q13 locus that includes cyclin D1 in luminal tumours [23], therefore suggesting that cyclin D1 high expression can be considered a 'luminal event'.