For example the MIT domain has been identified in spastin (responsible for the dominant form of spastic paraplegia) [36], spartin (recessive form of spastic paraplegia) [39], both proteins that interact with microtubules, or VSP4 [40] which is involved in the intracellular protein transport machinery and the regulation of membrane association of several proteins. This evidence concerns the gene SPART and Spastic paraplegia.