CHI3L1 and glioblastoma: In glioblastoma (GBM), where necrosis is a characteristic, both CHI3L1 expression and necrosis are associated with poor prognosis (Burger and Green, 1987; Raza et al, 2002; Pelloski et al, 2005; Homma et al, 2006; Kleihues et al, 2007).