As VEGF165 binds to NRP2 (Gluzman-Poltorak et al, 2000), competition between SEMA3B/3G and VEGF165 for binding to NRP2 might exist in gliomas as demonstrated for SEMA3A and NRP1 in ECs (Miao et al, 1999). Here, SEMA3B is linked to central nervous system cancer.