SEMA3F acts as a tumour suppressor gene by reducing angiogenesis and metastasis, probably through the inhibition of integrin-mediated adhesion and VEGF expression (Xiang et al, 2002; Kessler et al, 2004; Bielenberg et al, 2004; Kusy et al, 2005; Futamura et al, 2007; Potiron et al, 2007). This evidence concerns the gene VEGFA and neoplasm.