Recently, on the basis of the Affimetrix gene chip analysis of gliomas, it was shown that SEMA3B expression associated with poorer overall survival (OS) when combined with the expressions of two other genes, osteonectin/SPARC and doublecortex/doublecortin, which have key functions in cellular migration processes (Rich et al, 2005). The gene discussed is SPARC; the disease is central nervous system cancer.