Recently, on the basis of the Affimetrix gene chip analysis of gliomas, it was shown that SEMA3B expression associated with poorer overall survival (OS) when combined with the expressions of two other genes, osteonectin/SPARC and doublecortex/doublecortin, which have key functions in cellular migration processes (Rich et al, 2005). This evidence concerns the gene SEMA3B and central nervous system cancer.