As VEGF165 binds to NRP2 (Gluzman-Poltorak et al, 2000), competition between SEMA3B/3G and VEGF165 for binding to NRP2 might exist in gliomas as demonstrated for SEMA3A and NRP1 in ECs (Miao et al, 1999). The gene discussed is SEMA3A; the disease is central nervous system cancer.