Moreover, the serum level of IGF-1 or IGFBP-3 did not statistically differ between the two distinct IGF-1R overexpressions (P=0.77 and P=0.07, respectively), indicating no direct correlation between circulating IGF-1 or IGFBP-3, and IGF-1R overexpression in cervical cancer cells. The gene discussed is IGFBP3; the disease is cervical cancer.