Increase in E-cadherin immunoreactivity is highly associated with a worse prognosis of oral squamous cell carcinoma (OSCC), and the re-expression of E-cadherin in lymph node confers advantages to OSCC in metastasis environment (Imai et al, 2004; Hung et al, 2006). The gene discussed is CDH1; the disease is oral cavity squamous cell carcinoma.