In another very recent study, it has been shown that MUC4 interacts with ErbB2 in human gallbladder carcinoma and helps in the activation of erbB2 (Miyahara et al, 2008).Till date, information regarding the role of MUC4 in gastric cancer is very less, recently, it has been shown that specifically in poorly differentiated type gastric signet ring cell carcinoma cells, MUC4 is required for the activation of ErbB2. This evidence concerns the gene ERBB2 and signet ring cell carcinoma.