In our analysis of breast cancer cell lines and tumour samples, we found the expression of chemokine receptor CXCR5 to be restricted to the cytoplasma, a finding that is in line with observations of Muller et al (2006) who detected CXCR5 intracellulary but did not detect surface expression of CXCR5 in cell lines and tumour samples from patients with metastatic head and neck cancer. This evidence concerns the gene CXCR5 and neoplasm.