PPARγ activation results inits heterodimerization with the retinoid X receptor (RXR), binding toperoxisome proliferator response elements (PPREs) on DNA, and subsequentactivation of target gene expression [198].PPARγ is aberrantly expressed in some cancer types [199], and in manycases its activation leads to cell death or differentiation [191, 200, 201]. The gene discussed is PPARG; the disease is cancer.