An extensive tissue microarray study of 1808 invasive breastcarcinomas and 214 pre-invasive breast samples linked to clinical data hasshown that the level of CXCR4 expression can be linked to tumor progressivity(tumor grade and lymph node status) and to other prognostic factors such asHER2 expression and hormone receptor (ER and PR) negativity, as well as topatient survival [46]. Here, ESR1 is linked to neoplasm.