As noted, BADGE had similar proapoptoticeffects in a colon cancer line expressing PPARγ and a T-lymphoma line that showed nodetectable expression of it (by immunoblotting and RT-PCR) of this target [22].But, given the variable classification of this compound as both an antagonistand agonist, the mechanism underlying this effect and its attribution are unclear. The gene discussed is PPARG; the disease is malignant colon neoplasm.