Schaefer et al. showedthat the antiproliferative effect of the PPARγ antagonist, T0070907, onhepatocellular carcinoma cell lines was attenuated by knockdown of PPARγ by siRNA [25].These data are consistent with a PPARγ-mediated transrepression mechanism, which hasbeen demonstrated with respect to anti-inflammatory effects of PPARγ ligands mediated by the NF-κB signaling pathway. The gene discussed is PPARG; the disease is carcinoma.