COMT (catechol-O-methyltransferase) metabolizes catechol drugs, and has been linked to breast cancer risk and survival [36]; GHRL has been shown to stimulate angiogenesis [37] and regulate bone formation through osteoblasts [38,39]; FDFT is the farnesyl transferase that may regulate important signaling (eg, ras) [40,41]; and ABCC is among a class of transporters that may influence multi-drug resistance [42]. This evidence concerns the gene COMT and breast carcinoma.