TP53 and Kaposi's sarcoma: For example, Kaposi's sarcoma associated herpesvirus (KSHV) is associated with the pathogenesis of Kaposi's sarcoma, KSHV viral interferon regulatory factor1 (vIRF1) greatly reduced the level of serine 15 phosphorylation of p53, resulting in an decrease of p53 stability which could circumvent host growth surveillance and facilitate viral replication in infected cells [15].