The association between CCL3L1-CCR5 GRG status and CD4+ T cell loss and/or AIDS susceptibility was observed in two separate groups of subjects who were followed from the early stages of their infection within the context of a natural history cohort as well as in a separate cohort of subjects who were recruited during acute/early infection [5], [20], [23]. The gene discussed is CCL3L3; the disease is AIDS.