CCR5 and AIDS: Furthermore, we observed an enrichment of protective CCL3L1-CCR5 genotypes in subjects from a natural HIV-1 history cohort who were AIDS-free for more than 10 years, as well as in individuals from two different cohorts who were categorized as spontaneous HIV-1 controllers, i.e., elite or viremic controllers [20], [55], further underscoring that these genetic factors might play an important role in restricting disease progression.