The difference in the rate of progression from <450 to <200 cells/mm3 between those who were or were not assigned to a low GRG remained significant even after adjustment for the baseline CD4 cell count and viral load, the best DTH skin test reactivity recorded during disease course, and cohort membership in the calendar years 1990–1999, a time-period during which most of the AIDS events in this cohort occurred and HAART was available (Figure 3B, right). The gene discussed is CD4; the disease is AIDS.