EGLN2 located within the paired region was dramatically overexpressed in renal oncocytoma cells and was associated with the deregulation of numerous hypoxia-inducible genes including a pro-death BNIP3L. Thus, chromosome 19q pairing in renal oncocytoma unveils a unique mechanism of disrupting oxygen homeostasis via altering the expression of EGLN2. Here, SESN2 is linked to kidney oncocytoma.