SOX10 and demyelinating polyneuropathy: Furthermore, dominant-negative SOX10 mutations have been identified in patients with PCWH (OMIM Accession No. 609136), a complex syndrome characterized by the co-presentation of a WS4-like phenotype with central dysmyelinating leukodystrophy and demyelinating peripheral neuropathy consistent with Charcot-Marie-Tooth disease type I [11],[15].