MKI67 and neoplasm: As summarized in Table 2, in the entire series of 728 patients with complete follow-up data, multivariate analysis revealed that tumor size (HR 2.51, CI 1.40 to 4.50, P = 0.002), nodal status (HR 2.44, CI 1.62 to 3.66, P < 0.0001), and Ki67 proliferation index (HR 1.59, CI 1.08 to 2.34, P = 0.02) were independent prognostic variables influencing DFS.