On the other hand, the expressions of cyclin B2and myeloid cell leukemia sequence 1 were increased only in the hepatocellularadenoma tissues of PPARα-null mice.Taken together, DEHP may induce hepatocellular adenomas, partly via suppressionof G2/M arrest regulated by Gadd45α and caspase 3-dependent apoptosis in PPARα-null mice. This evidence concerns the gene PPARA and hepatocellular adenoma.