HPGD and non-small cell lung carcinoma: The nicotinamide adenine dinucleotidepositive-dependent catabolic enzyme 15-hydroxyprostaglandindehydrogenase (15-PGDH) metabolizes PGE2 to biologicallyinactive 15-keto derivatives.The final PGE2 concentration experienced by NSCLC cells depends upon expression ofPGES and 15-PGDH.