To determine whether overexpression of EGFR proteinand RNA might be related to an amplification of EGFR locus, we performed CISH and FISH analysis on eight MPNSTsamples of the main series (R72, R74, R78, R84, R85, R86, R92, R94, R111,R116), whose expression was either homogeneous (n = 2) or heterogeneous (n = 6).None of the tumour had evidence of EGFR amplification. The gene discussed is EGFR; the disease is neoplasm.