IL-10 is higher in severe malaria patients from different regions despite the fact that CM individuals presented lower levels of IL-10 in comparison to the non-cerebral malaria group [16], [56] Furthermore, CD8+ αβ T cells migrating to the brain have been implicated in cytotoxicity and BBB disruption, thus contributing to ECM mortality [14], [15]. The gene discussed is CD8A; the disease is cerebral malaria.