EPHA8 and colorectal cancer: Amongst the genes specifically expressed in all three clusters C, D and E were two transcription factors involved in brain development, FOXG1B and EOMES. Also LEMD1, a testis specific gene recently found to be overexpressed in colorectal cancer [41] and several genes involved in neuronal migration, like UNC5D and EPHA8, were specific for all tumors in clusters C, D and E (Figure 3C and Table S2).