Proliferative activity, as determined by expression levels of the Ki-67 nuclear antigen, has been linked to prognosis and treatment prediction with varying results in oral cancer, with few studies performed exclusively in OTSCC (Xie et al, 1999; Pich et al, 2004; Lothaire et al, 2006; Kim et al, 2007). This evidence concerns the gene MKI67 and lip and oral cavity carcinoma.