Microdontia of canines (Fig. 3c and d), dysmorphic cone-shaped incisors (d) and canines (c and d) and molar root fusion and shape anomalies (a and b) are associated with the phenotype of oligodontia and also linked to the ED1 mutation and molecular alterations of the EDA-NF-kappaB signalling pathway.92 The gene discussed is EDA; the disease is Oligodontia.