Based on these findings, we think that the estimation of CD52 expression may provide a rationale for the selection of patients with higher probability of responding to alemtuzumab, by avoiding the risk of unwanted toxicity.21 Similar conclusions were achieved by Rodig et al100 and Chang et al,101 who reported immunohistochemical detection of CD52 in 0–40% of PTCL. The gene discussed is CD52; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.