CD4 and angioimmunoblastic T-cell lymphoma: CD4 was detected in 46% of cases (see fig 1A) and CD8 in 15% of cases; these results are in line with those reported in previous publications.8, 11, 25, 28, 29 Interestingly, we found 32% of AITLs to be CD8+; this is in the upper range of reported values.27, 30–44 In contrast, the incidence of CD4 positivity (42%) was much lower than expected.27, 45 Interestingly, a huge number of PTCL/NOS and AITL (55%) turned out to be either CD4/CD8 double-negative or, more rarely, double-positive.