The authors found two different subgroups of PTCL based on the expression of NF-κB related genes. One-third of PTCL clearly showed reduced expression of NF-κB genes, while the other group was characterised by high expression of these genes. Of interest, the expression profile associated with reduced expression of NF-κB genes was significantly associated with shorter survival of patients. Here, NFKB1 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.