[5] The TAR DNA binding protein (TDP-43) is a nuclear protein implicated in exon splicing and transcription regulation, [6] and was recently identified as a major protein component of the ubiquitin-immunoreactive inclusions characteristic of sporadic and familial FTLD-U, with and without MND, as well as in sporadic cases of MND [7-9]. Here, TARDBP is linked to mild neurocognitive disorder.