TARDBP and early-onset autosomal dominant Alzheimer disease: The individual (III:2) with clinical Alzheimer's disease was found to have TDP-43 inclusions consistent with type 2 FTLD-U (Figure 2), with co-existing hippocampal sclerosis, as well as sufficient densities of cortical plaques and tangles but insufficient CA1 hippocampal neuritic pathology to fulfil criteria for Alzheimer's disease.