Importantly, dysfunctions of both, the liver and kidneys, are known to influence RBP4 homeostasis [13,16-18]: chronic kidney diseases (CKD) and chronic liver diseases (CLD) interfere with RBP4 metabolism through their action on RBP4 synthesis and catabolism [13,19]. This evidence concerns the gene RBP4 and congenital secretory chloride diarrhea 1.