We found the alternative splice in exon 15, which encodes the SER715− isoform of c-kit in tumour samples, but this variant, which has been reported in other tumour types by a number of investigators (Crosier et al, 1993; Ashman, 1999; Lasota et al, 2002), did not predict the response to imatinib. The gene discussed is KIT; the disease is neoplasm.