NRXN1 and autism: In another study, a de novo heterozygous 300 kb deletion in the coding exons of the NRXN1 gene was found in two affected sisters, who both received a diagnosis of autism.45 However, one girl was reported to be non-verbal, whereas the other had mild language regression.45 In a recent case–control study by Yan et al,46 five rare patient-specific variants were identified in 116 ASD individuals whereas only one additional variant (G28A) was also found in controls.