In spite of using both tTau, P-Tau and 14-3-3 protein for the diagnosis of CJD, our data suggest that there will still be a few patients with AD/VaD and OND that cannot be distinguished from CJD using the biomarkers tTau, P-Tau and 14-3-3 protein. This evidence concerns the gene MAPT and Creutzfeldt Jacob disease.