Osteoporosis, Parkinson disease, epilepsy, high blood pressure, use of angiotensin converting enzyme (ACE) inhibitors, antihistamines, analgesics, antiacids, alpha and beta-adrenergic blockers, nitrates, non steroidal anti-inflamatory drugs, digoxin, calcium and vitamin D supplements did not reached the pre-defined level of 0.25 significance [see Additional file 2]. The gene discussed is ACE; the disease is osteoporosis.