Interleukin-8, a cytokine of the CXC chemokine family, plays an important role in tumor progression and metastasis in a variety of human cancers, including lung cancers.33 Interleukin-8 biological activity in tumors and the tumor microenvironment may contribute to tumor progression through its potential function in the regulation of angiogenesis, cancer cell growth and survival, tumor cell motion, leukocyte infiltration, and modification of immune responses. This evidence concerns the gene CXCL8 and cancer.