TNF and allergic disease: Furthermore, TNF increased the expression of mRNA forendothelial-leukocyte adhesion molecule-1 (ELAM-1) and vascular cell adhesionmolecule-1 (VCAM-1), which are essential for eosinophil migration into allergicinflammatory site, in nasal mucosa after ovalbumin sensitization in mice [27],suggesting that inhibition of TNF production from mast cells throughIgE-dependent mechanisms may also partially account for the therapeuticmechanisms of the agent on allergic diseases.