The most studiedchange of DNA methylation in neoplasms is the silencing of tumor suppressorgenes by deoxy-cytidylatephosphate-deoxy-guanylate (CpG) island promoterhypermethylation, which targets genes and molecules associated in celldifferentiation, such as p16(INK4a), BRCA1, and hMLH1 [41–43]. This evidence concerns the gene CDKN2A and neoplasm.