These results indicated that higher-grade chondrosarcomacells may be resistant to apoptosis by overexpression of Bcl-xL, and 15d-PGJ2 might induce apoptotic celldeath by downregulation of Bcl-xL and transient upregulation of Bax [37].Similar results were reported in renal cell carcinoma cells (786-O and A498cells) showing the thiazolidinedione (TZD) induction of apoptosiswith increased Bax expression and decreased Bcl-2 expression [39]. Here, BAX is linked to hereditary clear cell renal cell carcinoma.