CDKN2A and neoplasm: Asp et al. analyzed p16 and p53 incartilaginous tumor tissues and showed that the p16 gene was found to be partlymethylated in 5 high-grade chondrosarcomas and homozygously deleted in 1chondrosarcoma, whereas the p53 gene revealed an unchanged structure in all 22chondrosarcoma samples [46].