Van Beerendonk et al. found p16 promoter methylation bymethylation-specific PCR in 5 of 30 tumors, but this did not correlate withprotein expression, or with loss of heterozygosity (LOH) at 9p21 region, one ofthe few consistent genetic aberrations found in conventional chondrosarcoma [44]. Here, CDKN2A is linked to chondrosarcoma.