Consistentwith the observation that PPARα ligands might act as potent directand/or indirect antiangiogenic factors, Panigrahy et al. have recently shownthat fenofibrate suppresses VEGF-mediated endothelial cell proliferation aswell as tumor cell-derived VEGF and FGF2 synthesis with concomitant stimulationof tumor-cells derived thrombospondin and endostatin [48]. The gene discussed is PPARA; the disease is neoplasm.