While these exo- and endogenous stimuli are normally not perceived as danger signals or are efficiently suppressed, the facilitated oligomerization of the cryopyrin/NALP3/CIAS1, which is not adequately suppressed by the mutated pyrin in FMF, may be the underlying cause in this disease, resulting in excessive pro-caspase-1 and pro-IL1β processing. The gene discussed is CASP1; the disease is familial Mediterranean fever.