CD8A and infection: This MRI study coupled with our previous work which determined that the majority of Db:VP2121–130 epitope specific CD8 T cells are predominantly found in the brain 7 days post TMEV infection and not in peripheral lymphoid compartments, supports the concept that active engagement of T cell receptor with antigen in the CNS is a likely contributor to vascular permeability following administration of intravenous VP2121–130 peptide [20], [23].