TFIZ1 is an 18.3 kDa secreted protein (Westley et al., 2005) encoded by one of two closely related genes on chromosome 2 (2p14), also known as GDDR (down-regulated in gastric cancer) (Du et al., 2003, 2005), blottin (Otto et al., 2006) and gastrokine 2 (GKN2) (Baus-Loncar et al., 2007). The gene discussed is GKN2; the disease is gastric cancer.