For the comparison of inter-individual gene expression variances between RA SM (n = 12) and NC SM (n = 9), 568 genes were used (307 with significantly higher variances in RA and 261 with significantly higher variances in NC; P ≤ 0.05, Bonferroni/Holm corrected Brown-Forsythe version of the Levene test), resulting in the identification of 129 affected KEGG pathways/complexes in total (Supplementary Table 1a; shown for IL13 and CXCL13 in Figure 1). The gene discussed is IL13; the disease is rheumatoid arthritis.