Overexpression of APRIL, in contrast, has not been associated with autoimmunity in mice but leads to enhanced IgM production, T-cell-independent type 2 humoral responses, and T-cell survival [28], while lack of APRIL is associated with enhanced numbers of effector/memory T cells and impaired IgA responses [29,30]. The gene discussed is TNFSF13; the disease is Autoimmunity.