PPARG and obesity due to melanocortin 4 receptor deficiency: Thus, these interactions influence CVD risk in different directions through effects on two different CVD risk factors: HDL cholesterol through the polymorphism in APOA1and triacylglycerol through the polymorphism in PPARA. The effects of Pro12Ala polymorphism in PPARG2 on type 2 diabetes and obesity are also reported.