Oxytocin infusion was given for all PPH cases; two-thirds were given intravenous oxytocin in bolus; and only one-third of cases received 0.2–0.4 mg ergometrine i.v. Six cases (four in the misoprostol group and two in the placebo group) were given an additional dose of 200–400 mcg misoprostol either rectally or sublingually. The gene discussed is OXT; the disease is pulmonary arterial hypertension.