Of the three genes from 22 genetic loci that have been identified for POAG using linkage analyses, myocilin (MYOC, OMIM 601652), optineurin (OPTN, OMIM 602432), and WD repeat-domain 36 (WDR36, OMIM 609669), none of these genes have been found to associate with POAG in African Americans, Afro Caribbeans or in West African populations [12], [13]. The gene discussed is OPTN; the disease is open-angle glaucoma.