Only one haplotype (BAT1 -22*1 in combination with TNFA -850*2) appeared to be significantly associated with risk for AD, but the observed Odds ratio was lower for this haplotype (OR = 1.54) than the OR for the single polymorphisms associated with AD risk (TNFA -850*1/2, OR = 1.8 and TNFA -850*2/2, OR = 2.7). The gene discussed is TNF; the disease is Alzheimer disease.