However TNFA -308*2 and linked alleles may mark increased risk [6,18] or protection [7,19] against AD, so we investigated TNFA -308 alleles singly or in haplotypic combination with polymorphisms in adjacent candidate genes to elucidate associations of these polymorphisms or haplotypic combinations of the respective alleles with AD pathology in an Australian cohort. Here, TNF is linked to Alzheimer disease.