The complexity of potential phenotypical effects as well as possible haplotypic associations of BAT1 -22 with other genes indicate that further studies are warranted to explore whether the BAT1-22*1 allele may confer an independent risk for AD other than just in haplotypic combination with TNFA -850*2 as observed in the current study. The gene discussed is DDX39A; the disease is Alzheimer disease.