CRP and coronary artery disorder: Using rs1130864 to explore the causal association of CRP levels with CHD risk is valid since individuals who are homozygous for the T allele (TT genotype) will have experienced on average higher levels of circulating CRP over their lifetime than other individuals (CT or CC genotype),[39] but potential confounding factors will be evenly distributed between these two groups of individuals (TT versus CT or CC), as demonstrated for all our cohorts in table 3.