CRP and coronary artery disorder: The use of genetic variants as instrumental variables to determine the causal association between circulating CRP and CHD provides an alternative to such a randomized controlled trial, with the advantage that this approach can be performed in existing datasets and may be more generalisable than a randomized controlled trial.[8], [9], [10] It has also been suggested that CRP genetic profiling might have clinical utility in predicting CHD risk.[20]