Furthermore we have previously shown that the rs1130864 SNP is associated with a shift in the whole distribution of CRP levels and not an increase, for example, only at the higher end or a decrease only at the lower end of the CRP distribution.[41] This whole-population shift in CRP levels should clearly be related to a whole-population shift in CHD risk if CRP were causally related to CHD and therefore our null finding is unlikely to be explained by missing individuals with CRP levels above or below a given threshold in relation to genotype. The gene discussed is CRP; the disease is coronary artery disorder.