That study suggested that there was no strong evidence for a causal association between CRP levels and CHD but the authors acknowledged that pooling of larger studies was required to increase confidence in this conclusion.[12] A number of other studies, which have not directly employed Mendelian randomization approaches and have included between 210 to 1062 CHD cases, have also found genetic variants within the CRP gene to be unrelated to prevalent and incident CHD events, despite these variants being associated with CRP levels.[13]–[17]. The gene discussed is CRP; the disease is coronary artery disorder.