There was no evidence of correlation between rs1130864-CRP concentration and rs1130864-CHD estimates from separate studies on either a scatter plot (not shown) or as measured by the correlation coefficient of −0.089 (p = 0.83), justifying our assumption of no correlation in our use of Fieller's theorem for estimating the confidence interval for the instrumental variables analysis (see website supplementary material for methods: Text S1). Here, CRP is linked to coronary artery disorder.