It has been suggested that the exploitation of the principles of Mendelian inheritance can be used to determine unconfounded and unbiased estimates of associations between non-genetic risk factors and disease outcomes,[8]–[10] and that this “Mendelian randomization” approach could provide useful insights into the nature of the association between CRP and CHD.[11] In this approach, the association of a genotype that influences the modifiable risk factor of interest (in this case CRP) with outcome (CHD) is explored. Here, CRP is linked to coronary artery disorder.