A very recently published study investigated associations of the type 2 diabetes risk alleles in JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, THADA, ADAMTS9, and NOTCH2 with obesity, insulin sensitivity, and insulin secretion in 4516 Danes [25]. Here, NOTCH2 is linked to obesity due to melanocortin 4 receptor deficiency.